抗體 名：ErbB-4 (C-7)抗體

規(guī)格：200ug

Santa Cruz是美國也是上zui大的抗體生產(chǎn)廠家，提供抗體種類多達(dá)兩萬多種，幾乎覆蓋了目前生命科學(xué)研究的各個新領(lǐng)域，其每種抗體又有多個克隆可選擇，并有對應(yīng)蛋白標(biāo)準(zhǔn)品及相關(guān)產(chǎn)品，為免疫學(xué)研究工作提供了大的方便。
產(chǎn)品介紹：

ErbB-4 (C-7)抗體基因信息：

The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum.